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LEPTOSPIROSIS

                                       
Dr.NISANTH PRABHAKARAN.  BAMS

An acute and severe infection by leptospira interrogans

Out of these most common are

           1.Leptospira icterohaemorrhagic of rats                     

               2.Leptospira canicola of dogs

               3.Leptospira Pomona of cattles and swine

 Mode of transmission:

·      By the ingestion of food and drink contaminated by the urine of reservoir animal.

·      It may enter through minor  skin lesions and probably via the conjunctiva.

 Incubation period:                                
 
2 to 20 days

TYPES

1.   ANICTERIC LEPTOSPIROSIS

2.   ICTERIC LEPTOSPIROSIS

  SIGNS & SYMPTOMS

·      High degree pyrexia

·      Chills

·      Abdominal pain

·      Severe headache

·      Myalgia

·      Marked conjunctival suffusion

·      Renal impairment

·      Hepatic impairment

·      Abnormal mental status

·      Hemorrhagic pneumonia

·      Hypotension

·      Signs of meningitis

·      Rash and adenopathy

 LAB INVESTIGATIONS :

·      In mild stage leptospires can be isolated

·      Leukocyte count may be normal or higher

·      Presence of urine bile, protein, casts and red cells

·      Increased S.Bilirubin, aminotransferase

·      Uremia

·      Increased S.creatinine and creatinine kinase

·      IgM EIA ( enzyme immunosorbent assay)

·      ELISA test

·      Lumbar puncture

COMPLICATIONS:

·      Myocarditis

·      Aseptic meningitis

·      Renal failure

  •     Pulmonary infiltrate with haemorrhage.


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