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Bantis Syndrome

by: ayurdoctor Published on29-05-19 02:49 PM
General Description about Banti’s Syndrome
Banti syndrome is a disorder of the spleen, the large, gland-like organ in the upper left side of the abdomen that produces red blood cells before birth and, in newborns, removes and destroys aged red blood cells, and plays a role in fighting infection. In the case of Banti syndrome, the spleen rapidly but prematurely destroys blood cells.
This syndrome is characterized by abnormal enlargement of the spleen (splenomegaly) due to obstruction of blood flow in some veins and abnormally increased blood pressure (hypertension) within the veins of the liver (e.g., hepatic or portal veins), or the spleen (splenic veins). 

Synonyms of Banti’s Syndrome

Banti's Disease
Hypersplenism
Idiopathic congestive splenomegaly
Idiopathic portal hypertension
Non-Cirrhotic Portal Hypertension (NCPH)

Causes of Banti’s Syndrome

Banti syndrome may occur due to a number of different factors causing obstruction of, and abnormally increased blood pressure (hypertension) within, certain veins of the spleen (splenic veins) or the liver (e.g., hepatic or portal veins). These may include abnormalities present at birth (congenital) of such veins, blood clots, or various underlying disorders causing inflammation and obstruction of veins (vascular obstruction) of the liver, such as cirrhosis. Increased arsenic intake has also been implicated in some cases. Also, cases have occurred in patients taking long-term azathioprine, particularly after kidney transplantation.

Signs & Symptoms of Banti’s Syndrome

In early stages, symptoms of Banti syndrome include weakness, fatigue, anemia , and abnormal enlargement of the spleen. As the disorder progresses, the anemia becomes more severe. The anemia may be aggravated by a bleeding esophagus that may cause vomiting of blood and the passage of dark stools composed of decomposing blood. Ultimately, in some cases, the liver itself becomes enlarged and subdivided by fibrous tissue (cirrhosis). However, the spleen enlargement in Banti syndrome is the primary symptom.
Patients with Banti syndrome bruise easily, are more likely to contract bacterial infections and carry a fever for longer periods of time.
Symptoms may also include abnormal accumulation of fluid in the abdominal cavity (ascites), weakness, fatigue; abnormally low levels of circulating red blood cells (anemia), white blood cells (leukopenia), and/or platelets (thrombocytopenia), and/or episodes of bleeding (hemorrhage) from the gastrointestinal tract.


Affected Populations by Banti’s Syndrome

Banti syndrome affects males and females equally. It is relatively common in parts of India and Japan, but rare in Western countries. Increased arsenic levels are present in drinking water in some countries and may contribute to regional differences in incidence.

Similar  Disorders of Banti’s Syndrome

Symptoms of the following disorders can be similar to those of Banti syndrome. Comparisons may be useful for a differential diagnosis:

Primary biliary cirrhosis is a chronic, progressive liver disorder that primarily affects females and typically becomes apparent during middle age. Obstruction of the small bile ducts is accompanied by yellow discoloration of the skin (jaundice). Excessive amounts of copper accumulate in the liver, and fibrous or granular hardening (induration) of the soft liver tissue develops. Although the exact cause of primary biliary cirrhosis is unknown, possible immunological, autoimmune, genetic, and/or environmental factors are under investigation as potential causes of the disorder. 
Gaucher disease is a rare, inherited metabolic disorder in which deficiency of the enzyme glucocerebrosidase results in the accumulation of harmful quantities of certain fats (lipids) throughout the body, especially within the bone marrow, spleen and liver. The symptoms and physical findings associated with Gaucher disease vary greatly from case to case, but may include: an abnormally enlarged liver and/or spleen (hepatosplenomegaly), low levels of circulating red blood cells (anemia), low levels of platelets (thrombocytopenia), and skeletal abnormalities. 

Felty syndrome is a rare form of rheumatoid arthritis, a disorder characterized by painful, stiff, and swollen joints. Major symptoms and physical findings of Felty syndrome include an unusually large spleen (splenomegaly) and abnormally low levels of certain white blood cells (neutophils [neutropenia]). As a result of neutropenia, affected individuals may have an increased susceptibility to certain infections. Other symptoms associated with Felty syndrome may include fatigue, fever, weight loss, and/or discoloration of patches of skin (brown pigmentation). The exact cause of Felty syndrome is unknown. It is believed to be an autoimmune disorder. 

Diagnosis of Banti’s Syndrome

The diagnosis of Banti syndrome my be confirmed by a thorough clinical evaluation and a variety of specialized tests, particularly advanced imaging techniques such as a splenic venography and magnetic resonance imaging (MRI). During MRI, a magnetic field and radio waves are used to create cross-sectional images of targeted parts of the body.





Source : 
https://rarediseases.org/rare-diseases/bantis-syndrome/
https://rarediseases.info.nih.gov/diseases/5888/bantis-syndrome

Note: The information provided in this report is not intended for diagnostic and treatment purposes . It is provided for informational purposes only. Ayurdoctor.com recommends that affected individuals seek the advice or counsel of their own personal physicians.

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